Diazepam binding inhibitor over-expression in mice causes hydrocephalus, decreased plasticity in excitatory synapses and impaired hippocampus-dependent learning and memory without altering seizure activity
Siiskonen, Hanna; Oikari, Sanna; Korhonen, Veli-Pekka; Pitkanen, Asla; Voikar, Vootele; Kettunen, Mikko; Hakumaki, Juhana; Wahlfors, Tiina; Pussinen, Raimo; Penttonen, Markku; Kiehne, Karlheinz; Kaasinen, Selma; Alhonen, Leena; Janne, Juhani; Herzig, Karl Heinz
Diazepam binding inhibitor (DBI) and its processing products are endogenous modulators of GABAA and linked to various brain disorders ranging from anxiety and drug dependence to epilepsy. To investigate the physiological role of endogenously expressed DBI in the brain we created a transgenic mouse line overexpressing DBI gene. Transgenic mice had a 37× increased protein expression and immunohistochemistry showed excessive glial expression in the infragranular region of the dentate gyrus....[Show more]
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|Source:||Molecular and Cellular Neuroscience|
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