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Pharmacological prevention of renal ischemia-reperfusion injury in a rat model

Deng, Yi; Li, Rachel; Yang, Yong Liang; Weiss, Steven; Smith, Paul


Introduction: Renal ischemia–reperfusion injury (IRI) can lead to significant morbidity and mortality. It remains a leading cause of acute kidney injury and is therefore an important issue in trauma and renal transplant surgery. Various pharmaceutical agents have been used in an attempt to dampen the harmful effects of IRI but few have been shown to be useful clinically. Riluzole, Lidocaine and Lamotrigine have been demonstrated to show anti-ischaemic properties in other organs; however, their...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: ANZ Journal of Surgery
DOI: 10.1111/ans.17381


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