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Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study

Pearson, Mark S; Tedla, Bemnet A; Mekonnen, Gebeyaw G; Proietti, Carla; Becker, Luke; Nakajima, Rie; Jasinskas, Al; Doolan, Denise L; Amoah, Abena S; Knopp, Stefanie; Field, Matthew


Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to find antibody biomarkers of schistosome infection, validate their diagnostic performance in samples from endemic populations, and evaluate their utility as point of care immunochromatographic tests (POC-ICTs) to diagnose urogenital schistosomiasis in the...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: The Lancet Microbe
DOI: 10.1016/S2666-5247(21)00150-6
Access Rights: Open Access


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