Quah, Ben; Barlow, Vaughan; McPhun, Virginia; Matthaei, Klaus; Hulett, Mark; Parish, Christopher
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen-specific CD4+ T cells (1). Despite this, the majority of B cells are thought to play only a limited role in CD4+ T cell activation because BCRs are clonotypically expressed. Here, we show, however, that activated B cells can, both in vitro and in vivo, rapidly donate their BCR to bystander B cells, a process that is mediated by...[Show more]
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