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Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel; Wijesundara, Danushka K; Modhiran, Naphak; Mordant, F; Li, Jerry; Avumegah, Michael S; McMillan, Christopher L D; Lackenby, Julia A; Guilfoyle, Kate; van Amerongen, Geert; Stittelaar, Koert; Ranasinghe, Charani

Description

Objectives: Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion-stabilised spike (S) protein, Sclamp, in combination with the licensed adjuvant MF59 ‘MF59C.1’ (Seqirus, Parkville, Australia). Methods: A panel recombinant Sclamp proteins were produced in Chinese hamster ovary and screened in vitro to select...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
URI: http://hdl.handle.net/1885/295622
Source: Clinical and Translational Immunology
DOI: 10.1002/cti2.1269
Access Rights: Open Access

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