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Expression and evolution of the mammalian brain gene Ttyh1

Matthews, Clayton; Shaw, John; Hooper Jones, Jane; Young, Ian; Crouch, Michael; Campbell, Hugh


Homologues of the Drosophila melanogaster tweety (tty) gene are present in mammals and Caenorhabditis elegans. The encoded proteins have five predicted membrane-spanning regions and recent findings suggest that some family members may be chloride channels. Phylogenetic analysis of the tty family including novel members from slime mould Entamoeba and plants has revealed the occurrence of independent gene duplication events in different lineages. expressed sequence tag data indicate that...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Neurochemistry
DOI: 10.1111/j.1471-4159.2006.04237.x


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