Genome-wide characterization of the routes to pluripotency
Hussein, Samer M I; Puri, Mira C; Tonge, Peter D; Benevento, Marco; Corso, Andrew J; Clancy, Jennifer; Mosbergen, Rowland; Li, Mira; Lee, D. S; Cloonan, Nicole; Wood, David L A; Munoz, Javier; Middleton, Robert; Korn, Othmar; Patel, Hardip; White, Carl A; Shin, Jong-Yeon; Gauthier, Maely E; Lê Cao, Kim-Anh; Kim, Jong-Il; Mar, J. C; Shakiba, Nika; Ritchie, William; Rasko, John E. J; Grimmond, Sean M; Zandstra, Peter W; Wells, Christine; Preiss, Thomas; Seo, Jeong-Sun; Heck, Albert J. R.; Rogers, Ian M; Nagy, Andras
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the reprograming process. To address this gap in knowledge, we generated extensive transcriptomic, epigenomic and proteomic data sets describing the reprogramming routes leading from mouse embryonic fibroblasts to induced pluripotency. Through integrative analysis, we reveal that cells...[Show more]
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