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Differentiation of regulatory Foxp3+ T cells in the thymic cortex

Liston, Adrian; Nutsch, Katherine; Farr, Andrew; Lund, Jennifer; Rasmussen, Jeffery; Koni, Pandelakis; Rudensky, Alexander

Description

Regulatory Foxp3+ T cells (TR) are indispensable for preventing autoimmune pathology in multiple organs and tissues. During thymic differentiation T cell receptor (TCR)-ligand interactions within a certain increased affinity range, in conjunction with γc

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/29475
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0801506105

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