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Divergent reprogramming routes lead to alternative stem-cell states

Tonge, Peter D; Corso, Andrew J; Hussein, Samer M I; Monetti, Claudio; Puri, Mira C; Michael, Iacovos P; Li, Mira; Lee, DS; Clancy, Jennifer; Preiss, Thomas; Mar, JC; Cloonan, Nicole

Description

Pluripotency is defined by the ability of a cell to differentiate to the derivatives of all the three embryonic germ layers: ectoderm, mesoderm and endoderm. Pluripotent cells can be captured via the archetypal derivation of embryonic stem cells or via somatic cell reprogramming. Somatic cells are induced to acquire a pluripotent stem cell (iPSC) state through the forced expression of key transcription factors, and in the mouse these cells can fulfil the strictest of all developmental assays...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/29388
Source: Nature
DOI: 10.1038/nature14047

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