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Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region

Suzkuki, Kazuo; Juelich, Torsten; Lim, Heidi; Ishida, Takaomi; Watanebe, Toshiki; Cooper, David A; Rao, Sudha; Kelleher, Anthony D


In some mammalian systems small interfering RNAs (siRNA) targeting homologous sequences in promoter regions of genes induce transcriptional gene silencing (TGS). We have previously reported the induction of TGS by an siRNA (prom-A siRNA) targeting the tandem NF-κB-binding motifs within the human immunodeficiency virus, type 1 (HIV-1), promoter region. Here we report that induction of TGS by prom-A siRNA is accompanied by immediate and sustained local recruitment of Argonaute-1 (Ago1), histone...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M709651200


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