Axon growth and guidance genes identify T-dependent germinal centre B cells
Yu, Di; Cook, Matthew; Shin, Dong-Mi; Silva, Diego; Marshall, Jennifer; Toellner, Kai-Michael; Havran, Wendy L.; Caroni, Pico; Cooke, Michael P; Morse, Herbert C.; MacLennan, Ian CM; Goodnow, Christopher; Garcia De Vinuesa, Maria Carola
Selection of B cells subjected to hypermutation in germinal centres (GC) during T cell-dependent (TD) antibody responses yields memory cells and long-lived plasma cells that produce high affinity antibodies biased to foreign antigens rather than self-antigens. GC also form in T-independent (TI) responses to polysaccharide antigens but failed selection results in GC involution and memory cells are not generated. To date there are no markers that allow phenotypic distinction of T-dependent and TI...[Show more]
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