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Enalapril Treatment Alters the Contribution of Epoxyeicosatrienoic Acids but Not Gap Junctions to Endothelium-Derived Hyperpolarizing Factor Activity in Mesenteric Arteries of Spontaneously Hypertensive Rats

Ellis, Anthie; Goto, Kenichi; Chaston, Daniel; Brackenbury, Therese; Meaney, Kate; Falck, J.R; Wojcikiewicz, Richard J H; Hill, Caryl


Reduction in endothelium-derived hyperpolarizing factor (EDHF)-mediated dilatory function in large, elastic arteries during hypertension is reversed after blood pressure normalization. We investigated whether similar mechanisms occurred in smaller mesenteric resistance arteries from aged Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHRs), and SHRs treated with the angiotensin-converting enzyme inhibitor, enalapril, using immunohistochemistry, serial-section electron microscopy,...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.109.152116


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