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Mammary tumor modifiers in BALB/cJ mice heterozygous for p53

Koch, Joanna G; Gu, Xiangjun; Han, Younghun; El-Naggar, Adel K; Olson, Melissa V; Medina, Daniel; Jerry, Joseph; Blackburn, Anneke; Peltz, Gary; Amos, Christopher I; Lozano, Guillermina


BALB/c mice are predisposed to developing spontaneous mammary tumors, which are further increased in a p53 heterozygous state. C57BL/6J mice are resistant to induced mammary tumors and develop less than 1% mammary tumors in both wild-type and p53+/- states. To map modifiers of mammary tumorigenesis, we have established F1 and F2 crosses and backcrosses to BALB/cJ (N2-BALB/cJ) and C57BL/6J (N2-C57BL/6J) strains. All cohorts developed mammary carcinomas in p53+/- females, suggesting that multiple...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Mammalian Genome
DOI: 10.1007/s00335-007-9028-2


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