The strand bias paradox of somatic hypermutation at immunoglobulin loci
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Franklin, Andrew; Blanden, Robert
Description
Somatic hypermutation has two phases: phase 1 affects cytosine-guanine (C/G) pairs and is triggered by the deamination of cytosine residues in DNA to uracil; phase 2 affects mostly adenine-thymine (A/T) pairs and is induced by the detection of uracil lesions in DNA. It is not known how, at V(D)J genes in mice, hypermutations accumulate at A/T pairs with strand bias without perturbing the strand unbiased accumulation of hypermutations at C/G pairs. Additionally, it is not known why, in contrast,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/28952 |
Source: | Trends in Immunology |
DOI: | 10.1016/j.it.2008.01.008 |
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01_Franklin_The_strand_bias_paradox_of_2008.pdf | 550.25 kB | Adobe PDF | ![]() |
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