Skip navigation
Skip navigation

The strand bias paradox of somatic hypermutation at immunoglobulin loci

Franklin, Andrew; Blanden, Robert


Somatic hypermutation has two phases: phase 1 affects cytosine-guanine (C/G) pairs and is triggered by the deamination of cytosine residues in DNA to uracil; phase 2 affects mostly adenine-thymine (A/T) pairs and is induced by the detection of uracil lesions in DNA. It is not known how, at V(D)J genes in mice, hypermutations accumulate at A/T pairs with strand bias without perturbing the strand unbiased accumulation of hypermutations at C/G pairs. Additionally, it is not known why, in contrast,...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Trends in Immunology
DOI: 10.1016/


File Description SizeFormat Image
01_Franklin_The_strand_bias_paradox_of_2008.pdf550.25 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator