Skip navigation
Skip navigation
A change is coming. Click to see a sneak peek of the new Open Research Repository.

A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus

Download (164.23 kB)

link to publisher version

  • Altmetric Citations

Moutaftsi, Magdalini; Peters, Bjoern; Pasquetto, Valerie; Tscharke, David; Sidney, John; Bui, Huynh-Hoa; Grey, Howard; Sette, Alessandro

Description

The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any...[Show more]

dc.contributor.authorMoutaftsi, Magdalini
dc.contributor.authorPeters, Bjoern
dc.contributor.authorPasquetto, Valerie
dc.contributor.authorTscharke, David
dc.contributor.authorSidney, John
dc.contributor.authorBui, Huynh-Hoa
dc.contributor.authorGrey, Howard
dc.contributor.authorSette, Alessandro
dc.date.accessioned2015-12-08T22:09:09Z
dc.identifier.issn1087-0156
dc.identifier.urihttp://hdl.handle.net/1885/28900
dc.description.abstractThe value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
dc.publisherNature Publishing Group
dc.sourceNature Biotechnology
dc.subjectKeywords: Algorithms; Antigens; Biomarkers; Biotechnology; Cell culture; Mathematical models; Viruses; Breadth; Consensus epitopes; Predicitve algorithms; T-cell; Cells; cytokine; DNA polymerase; epitope; gamma interferon; major histocompatibility antigen class 1;
dc.titleA consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume24
dc.date.issued2006
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu4325460xPUB61
local.type.statusPublished Version
local.contributor.affiliationMoutaftsi, Magdalini, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationPeters, Bjoern, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationPasquetto, Valerie, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationTscharke, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSidney, John, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationBui, Huynh-Hoa, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationGrey, Howard, La Jolla Institute for Allergy and Immunology
local.contributor.affiliationSette, Alessandro, La Jolla Institute for Allergy and Immunology
local.description.embargo2037-12-31
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage817
local.bibliographicCitation.lastpage19
local.identifier.doi10.1038/nbt1215
dc.date.updated2015-12-08T07:22:33Z
local.identifier.scopusID2-s2.0-33746132748
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Moutaftsi_A_consensus_epitope_prediction_2006.pdf164.23 kBAdobe PDFThumbnail
Show simple item record


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator