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A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus

Moutaftsi, Magdalini; Peters, Bjoern; Pasquetto, Valerie; Tscharke, David; Sidney, John; Bui, Huynh-Hoa; Grey, Howard; Sette, Alessandro

Description

The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/28900
Source: Nature Biotechnology
DOI: 10.1038/nbt1215

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