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Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis

Knott, Michelle L.; Matthaei, Klaus; Giacomin, Paul R; Wang, Hui; Foster, Paul S; Dent, Lindsay


Eosinophils are an important feature of immune responses to infections with many of the tissue-invasive helminth parasites. The cytokine IL-5 and a high-affinity double GATA-binding site within the GATA-1 promoter are critical for eosinophilopoiesis. In this study, we believe we demonstrate for the first time that defects in eosinophilopoiesis are associated with impaired resistance to Nippostrongylus brasiliensis. Primary and secondary infections were established in wildtype (WT), IL-5-/- and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: International Journal for Parasitology
DOI: 10.1016/j.ijpara.2007.04.006


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