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Interferon type 1 responses in primary and secondary infections

Alsharifi, Mohammed; Mullbacher, Arno; Regner, Matthias


The mammalian host responds to a microbial infection with a rapid innate immune reaction that is dominated by type I interferon (IFN-I) release. Most cells of vertebrates can respond to microbial attack with IFN-I production, but the cell type responsible for most of the systemic IFN-I release is thought to be plasmacytoid dendritic cells (pDCs). Besides its anti-microbial and especially anti-viral properties IFN-I also exerts a regulatory role on many facets of the sequential adaptive immune...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/sj.icb.7100159


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