Skip navigation
Skip navigation

Identification of therapeutic drug targets through genetically manipulated mice: Are we getting it right?

Matthaei, Klaus

Description

A significant contribution to the identification of therapeutic targets in disease control and management has been made through the use of genetically modified mice in which specific gene function was altered. However, the genetic background of these mice can have a strong influence on the observed phenotype and, if not properly controlled, can lead to misinterpretation of data and incorrect conclusions as to the importance of particular genes in disease states. Nevertheless, it is becoming...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/28781
Source: Pharmacology and Therapeutics
DOI: 10.1016/j.pharmthera.2009.03.016

Download

File Description SizeFormat Image
01_Matthaei_Identification_of_therapeutic_2009.pdf190.53 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator