Identification of therapeutic drug targets through genetically manipulated mice: Are we getting it right?
A significant contribution to the identification of therapeutic targets in disease control and management has been made through the use of genetically modified mice in which specific gene function was altered. However, the genetic background of these mice can have a strong influence on the observed phenotype and, if not properly controlled, can lead to misinterpretation of data and incorrect conclusions as to the importance of particular genes in disease states. Nevertheless, it is becoming...[Show more]
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|Source:||Pharmacology and Therapeutics|
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