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Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy

Clark, Richard H; Kenyon, Julia C; Bartlett, Nathan W.; Tscharke, David; Smith, Geoffrey

Description

Vaccinia virus (VACV) is the vaccine that was used to eradicate smallpox and is being developed as a recombinant vaccine for other pathogens. Removal of genes encoding immunomodulatory proteins expressed by VACV may enhance virus immunogenicity and improve its potential as a vaccine. Protein A41 is a candidate for removal, having sequence similarity to the VACV chemokine-binding protein, vCKBP, and an association with reduced inflammation during dermal infection. Here, it is shown that, at low...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/28761
Source: Journal of General Virology
DOI: 10.1099/vir.0.81417-0

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