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Progression of Lipodystrophy (LD) with continued thymidine analogue usage: long-term follow-up from a randomized clinical trial (the PIILR Study)

Martin, Allison; Smith, Don; Carr, Andrew; Hoy, Jennifer; Chuah, John; Mallal, Simon; Law, Matthew G; Clements, Mark; Cooper, David A


Purpose: During the 24-week PIILR study of protease inhibitor (PI) withdrawal, improved lipids and reduction in intraabdominal visceral fat was seen, however, there was also a loss of subcutaneous limb fat in patients with HIV-lipodystrophy (LD). It was hypothesized that overall improvement in LD may require a longer period of time off Pls. Method: Follow-up of patients randomized to stop or continue PI-based therapy for 24 weeks, in a multicenter study, was continued for up to 120 weeks....[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: HIV Clinical Trials
DOI: 10.1310/0GU7-6X27-MMHE-5ALE


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