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Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease

Klaver, David W.; Wilce, Matthew C.J.; Gasperini, Robert; Freeman, Craig; Juliano, John Paul; Foa, Lisa; Aguilar, Marie-Isabel; Small, David H; Parish, Christopher


The β-site APP cleaving enzyme (BACE1) is responsible for the first step in the production of the β-amyloid protein of Alzheimer's disease. BACE1 is synthesized as a partially active zymogen (proBACE1). We previously showed that the glycosaminoglycan (G

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Neurochemistry
DOI: 10.1111/j.1471-4159.2010.06571.x


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