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Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

Simon Davis, David Anak; Parish, Christopher


Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues. Synthesized attached to various core proteins to form HS-proteoglycans, HS is capable of interacting with various polypeptides and exerting diverse functions. In fact, a bioinformatics analysis of mammalian proteins that express a heparin/HS-binding motif and are associated with the...[Show more]

CollectionsANU Research Publications
Date published: 2013-12-18
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2013.00470


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