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Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design

Wijesundara, Danushka Kumara; Xi, Yang; Ranasinghe, Charani


It has been well-established that type I interferons (IFN-Is) have pleiotropic effects and play an early central role in the control of many acute viral infections. However, their pleiotropic effects are not always beneficial to the host and in fact several reports suggest that the induction of IFN-Is exacerbate disease outcomes against some bacterial and chronic viral infections. In this brief review, we probe into this mystery and try to develop answers based on past and recent studies...[Show more]

CollectionsANU Research Publications
Date published: 2014-08-29
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2014.00412


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