Wijesundara, Danushka Kumara; Xi, Yang; Ranasinghe, Charani
It has been well-established that type I interferons (IFN-Is) have pleiotropic effects and play an early central role in the control of many acute viral infections. However, their pleiotropic effects are not always beneficial to the host and in fact several reports suggest that the induction of IFN-Is exacerbate disease outcomes against some bacterial and chronic viral infections. In this brief review, we probe into this mystery and try to develop answers based on past and recent studies...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.