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The challenge of managing adrenocortical carcinoma: two case studies

Kanjanapan, Yada; Prasanna, Thiru; Perampalam, Sumathy; Yip, Desmond


Adrenocortical carcinoma is a rare entity affecting 1–2 people per million. It has a relatively poor prognosis, with an overall 5-year survival of 20–45%. The reasons include a high risk of recurrence following resection and relatively poor response to cytotoxic treatment. The use of the adrenalytic mitotane as adjuvant therapy is supported by level III evidence from cohort studies. In the metastatic setting, one randomized controlled trial provides level II evidence for a three-drug...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: International Journal of Endocrine Oncology
DOI: 10.2217/ije.15.12


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