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Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Tu, Wen Juan; McCuaig, Robert; Tan, Abel; Hardy, Kristine; Seddiki, Nabila; Ali, Sayed; Dahlstrom, Jane; Bean, Elaine; Dunn, J; Forwood, Jade Kenneth; Yip, Desmond; Malik, Laeeq


Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast cancer stem cells. Here we show that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients express higher levels of nLSD1p compared to responders, which is associated with co-expression of stem-like, mesenchymal genes. Targeting...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.01228
Access Rights: Open Access


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