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Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease

Horvat, Jay C; Beagley, Kenneth W; Wade, Margaret A; Preston, Julie A; Hansbro, Nicole; Hickey, Danica K; Kaiko, Gerard E; Gibson, Peter G; Foster, Paul S; Hansbro, Phil M

Description

Rationale: Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown. Objectives: To determine the effect of chlamydial infection at various ages on the development of allergic airway disease (AAD). Methods: Mousemodels of chlamydial lung infectionand ovalbumin-induced AAD were established in neonatal and adult BALB/c mice. Neonatal or adult mice were...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/28425
Source: American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.200607-1005OC

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