AmAMP1 from Acropora millepora and damicornin define a family of coral-specific antimicrobial peptides related to the Shk toxins of sea anemones
Mason, B.; Cooke, I.; Moya, A.; Augustin, R.; Lin, M.F.; Satoh, N.; Bosch, Thomas CG; Bourne, D.G.; Hayward, David; Andrade, Natalia; Foret, Sylvain; Ying, Hua; Ball, Eldon; Miller, David J.
A candidate antimicrobial peptide (AmAMP1) was identified by searching the whole genome sequence of Acropora millepora for short (<125AA) cysteine-rich predicted proteins with an N-terminal signal peptide but lacking clear homologs in the SwissProt database. It resembled but was not closely related to damicornin, the only other known AMP from a coral, and was shown to be active against both Gram-negative and Gram-positive bacteria. These proteins define a family of AMPs present in corals and...[Show more]
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