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Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta

Theodoratos, Angelo; Tu, Wen (Sherry); Cappello, Jean; Blackburn, Anneke; Matthaei, Klaus; Board, Philip


Glutathione transferase Zeta (GSTZ1-1) is identical to maleylacetoacetate isomerase and catalyses a significant step in the catabolism of phenylalanine and tyrosine. Exposure of GSTZ1-1 deficient mice to high dietary phenylalanine causes a rapid loss of circulating white blood cells (WBCs). The loss was significant (P < 0.05) after 2 days and total WBCs were reduced by 60% after 6 days. The rapid loss of WBCs was attributed to the accumulation of the catabolic intermediates maleylacetoacetate...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2009.01.017


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