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Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara

Smith, Caroline L; Mirza, Fareed; Pasquetto, Valerie; Tscharke, David; Palmowski, M J; Dunbar, P Rod; Sette, Alessandro; Harris, Adrian L; Cerundolo, V


Many recombinant poxviral vaccines are currently in clinical trials for cancer and infectious diseases. However, these agents have failed to generate T cell responses specific for recombinant gene products at levels comparable with T cell responses associated with natural viral infections. The recent identification of vaccinia-encoded CTL epitopes, including a new epitope described in this study, allows the simultaneous comparison of CTL responses specific for poxviral and recombinant epitopes....[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Immunology


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