Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production
Poisbeau, Pierrick; Patte-Mensah, Christine; Keller, Florence A; Barrot, Michel; Breton, Jean-Didier; Luis-Delgardo, Olivia Erendira; Freund-Mercier, Marie Jose; Mensah-Nyagan, Ayikoe Guy; Schlichter, Remy
Inhibitory synaptic transmission in the dorsal horn (DH) of the spinal cord plays an important role in the modulation of nociceptive messages because pharmacological blockade of spinal GABAA receptors leads to thermal and mechanical pain symptoms. Here, we show that during the development of thermal hyperalgesia and mechanical allodynia associated with inflammatory pain, synaptic inhibition mediated by GABAA receptors in lamina II of the DH was in fact markedly increased. This phenomenon was...[Show more]
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|Source:||Journal of Neuroscience|
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