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Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis

Yu, Jun; Chu, Eagle S. H.; Hui, Alex Y.; Cheung, Kin F; Chan, Henry L. Y.; Leung, Wai K.; Farrell, Geoffrey; Sung, Joseph J Y


Dietary model of steatohepatitis was established by feeding mice a methionine choline deficient (MCD) diet. Mice on MCD or control diet for 3 weeks were treated with or without NO-1886, a newly synthetic lipoprotein lipase (LPL) activator. In a separate experiment, NO-1886 was given after pre-treatment with 3 weeks of MCD diet. NO-1886 significantly reduced MCD-induced inflammation by repressing levels of hepatic lipid peroxides and pro-inflammatory tumor necrosis factor-alpha (TNF-α),...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2007.02.129


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