Genetic analysis of systemic autoimmunity
Even for complex diseases with high rates of monozygotic twin concordance, disease-associated alleles remain elusive. One explanation is that multiple common genetic variants with weak effects cause these diseases and identification of any single allele requires large cohorts. Conversely, if the allelic spectrum of complex disease is heterogeneous, strong effects of rare variants might be offset by their presence in only a small proportion of the patient population. Lupus (SLE) is a systemic...[Show more]
|Collections||ANU Research Publications|
|Book Title:||Decoding the genomic control of immune reactions: Novartis Foundation Symposium, No 281|
|01_Garcia De Vinuesa_Genetic_analysis_of_systemic_2007.pdf||3.74 MB||Adobe PDF||Request a copy|
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