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Genetic analysis of systemic autoimmunity

Garcia De Vinuesa, Maria Carola; Cook, Matthew


Even for complex diseases with high rates of monozygotic twin concordance, disease-associated alleles remain elusive. One explanation is that multiple common genetic variants with weak effects cause these diseases and identification of any single allele requires large cohorts. Conversely, if the allelic spectrum of complex disease is heterogeneous, strong effects of rare variants might be offset by their presence in only a small proportion of the patient population. Lupus (SLE) is a systemic...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Book chapter


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