Wang, Yanan; Qin, Qing Hua; Kalyanasundaram, Shankar
A mathematical model is developed for simulating anabolic behaviour of bone affected by Parathyroid Hormone (PTH) in this paper. The model incorporates a new understanding on the interaction of PTH and other factors with the RANK-RANKL-OPG pathway into bone remodelling, which is able to simulate anabolic actions of bone induced by PTH at cellular level. The RANK-RANKL-OPG pathway together with the dual action of TGF-Β, which represent the core of coupling behaviour between osteoblasts and...[Show more]
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