In vitro modulation of the cardiac ryanodine receptor activity by Homer1
The Homer protein family allows clustering and/or functional modulation of many proteins from different calcium signalling complexes including those formed by the ryanodine receptor (RyR) Ca2+ release channel in skeletal muscle and the heart. Homer1b/c and the cardiac RyR (RyR2) are strongly expressed in the heart and neurons where their interaction with each other may modulate Ca2+ signalling. However, functional interactions between Homer1b and RyR2 have been poorly defined. Our preliminary...[Show more]
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|Source:||Pflugers Archives European Journal of Physiology|
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