Production of 5alpha-reduced neurosteroids Is developmentally regulated and shapes GABA(A) miniture IPSCs in lamina II of the spinal cord.
In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABAA and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABA A and glycine receptors in immature (<30 d) and adult rats. Blockade of neurosteroidogenesis by...[Show more]
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|Source:||Journal of Neuroscience|
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