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Production of 5alpha-reduced neurosteroids Is developmentally regulated and shapes GABA(A) miniture IPSCs in lamina II of the spinal cord.

Keller, Florence A; Breton, Jean-Didier; Schlichter, Remy; Poisbeau, Pierrick


In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABAA and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABA A and glycine receptors in immature (<30 d) and adult rats. Blockade of neurosteroidogenesis by...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.4642-03.2004


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