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Noradrenaline increases mEPSC frequency in pyramidal cells in layer II of rat barrel cortex via calcium release from presynaptic stores

Choy, Julian; Agahari, Fransiscus; Li, Li; Stricker, Christian


Somatosensory cortex is innervated by afferents originating from the locus coeruleus which typically release noradrenaline. We tested if activation of presynaptic α1-adrenoceptors (AR) coupled to a Gq-mediated signaling cascade resulted in calcium (Ca2+) release from stores and thereby increased spontaneous transmitter release in rat barrel cortex. Adding 1–100 μM noradrenaline (NA) or 5 μM cirazoline (CO), a α1-AR specific agonist, to the standard artificial cerebrospinal fluid increased the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Frontiers in Cellular Neuroscience
DOI: 10.3389/fncel.2018.00213
Access Rights: Open Access


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