DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
Skvortsova, Ksenia; Masle-Farquhar, Etienne; Luu, Phuc-Loi; Song, Jenny Z; Qu, W; Zotenko, Elena; Gould, Cathryn M.; Du, Qian; Peters, Timothy J.; Colino-Sanguino, Yolanda; Miosge, Lisa; Reed, Joanne; Goodnow, Christopher; Nair, Shalima S; Horvath, Lisa G.; Polo, Jose M
Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we identified CpG islands that display partial methylation encroachment across the 5′ or 3′ CpG island borders. CpG island methylation encroachment is widespread in prostate and breast cancer and commonly associates with gene suppression. We show that the pattern of H3K4me1 at CpG island borders in normal cells predicts the different modes of...[Show more]
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