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IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Wang, Huimeng; Kjer-Nielsen, Lars; Shi, Mai; D'Souza, Criselle; Pediongco, Troi J.; Cao, Hanwei; Kostenko, Lyudmila; Lim, Xin Yi; Eckle, Sidonia BG; Meehan, Bronwyn; Yu, Di


Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthesis pathway, including 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), bound to MHC-related protein-1 (MR1). However, MAIT cell activation in vivo has not been studied in detail. Here, we have found and characterized additional molecular signals required for optimal activation and expansion of MAIT cells after pulmonary Legionella or Salmonella infection...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Science Immunology
DOI: 10.1126/sciimmunol.aaw0402


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