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A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Koay, Hui Fern; Su, S.; Amman-Zalcenstein, D.; Daley, Stephen; Comerford, Iain; Miosge, Lisa; Whyte, C. E.; Konstantinov, Igor E; d'Udekem, Yves; Baldwin, Timothy; Hickey, P. F.; Berzins, Stuart P; Sontani, Yovina; Roots, Carla


MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymically through a three-stage process, but the events that regulate this are largely unknown. Here, using bulk and single-cell RNA sequencing–based transcriptomic analysis in mice and humans, we studied the changing transcriptional landscape that accompanies transition through each stage. Many transcripts were sharply modulated during MAIT cell development,...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Science Immunology
DOI: 10.1126/sciimmunol.aay6039


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