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Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Wu, Ting; Guan, Jing; Handel, Andreas; Tscharke, David; Sidney, John; Sette, Alessandro; Wakim, Linda M.; Sng, Xavier Y. X.; Thomas, Paul G; Croft, Nathan P; Purcell, Anthony; La Gruta, Nicole L


The magnitude of T cell responses to infection is a function of the naïve T cell repertoire combined with the context and duration of antigen presentation. Using mass spectrometry, we identify and quantify 21 class 1 MHC-restricted influenza A virus (IAV)-peptides following either direct or cross-presentation. All these peptides, including seven novel epitopes, elicit T cell responses in infected C57BL/6 mice. Directly presented IAV epitopes maintain their relative abundance across distinct...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Nature Communications
DOI: 10.1038/s41467-019-10661-8
Access Rights: Open Access


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