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T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Deng, Jun; Wei, Yunbo; Fonseca, Válter R; Graça, Luís; Yu, Di


As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity maturation in germinal centre reactions and humoral memory formation, whereas TFR cells suppress TFH cell-mediated antibody responses. Evidence...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Nature Reviews Rheumatology
DOI: 10.1038/s41584-019-0254-2


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