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A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells

Yu, Di; Ye, Lilin

Description

CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune clearance of infected and cancerous cells and provide long-term protection. Recent research identified a CXCR5+Tcf1+Tim-3− subset that localizes in, or proximal to, B cell follicles in secondary lymphoid organs of mice, non-human primates, and humans, hereby termed follicular cytotoxic T (TFC) cells. With remarkable similarity to follicular helper T (TFH) cells, TFC differentiation is dependent on...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/281395
Source: Trends in Immunology
DOI: 10.1016/j.it.2018.10.002

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