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Role of allergen-specific T-follicular helper cells in immunotherapy

Yao, Yin; Wang, Zhi-Chao; Yu, Di; Liu, Zheng


Purpose of review The discovery of novel T-cell subsets including follicular helper T (Tfh) cells has broadened our knowledge on the complex immune networks in allergic diseases. This review summarizes the evidence for Tfh cells in controlling immune responses to allergens with a particular focus on immunoglobulin E (IgE) production and discusses the implication of such regulation in allergen-specific immunotherapy. Recent findings Tfh cells support the production of IgE in animal models for...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Current Opinion in Allergy and Clinical Immunology
DOI: 10.1097/ACI.0000000000000480


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