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Functional paralysis of human natural killer cells by alphaherpesviruses

Campbell, Tessa Mollie; McSharry, Brian Patrick; Steain, Megan; Russell, Tiffany A; Tscharke, David; Kennedy, Jarrod John; Slobedman, Barry; Abendroth, Allison


Natural killer (NK) cells are implicated as important anti-viral immune effectors in varicella zoster virus (VZV) infection. VZV can productively infect human NK cells, yet it is unknown how, or if, VZV can directly affect NK cell function. Here we demonstrate that VZV potently impairs the ability of NK cells to respond to target cell stimulation in vitro, leading to a loss of both cytotoxic and cytokine responses. Remarkably, not only were VZV infected NK cells affected, but VZV antigen...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1007784
Access Rights: Open Access


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