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Homer and the ryanodine receptor

Pouliquin, Pierre; Dulhunty, Angela


Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca2+ release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins. Many Homer proteins can also self-associate through a coiled-coil domain that allows their multimerisation. In other tissues, especially neurons, Homer anchors proteins embedded in the surface membrane to the Ca2+ release channel in the endoplasmic...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: European Biophysics Journal
DOI: 10.1007/s00249-009-0494-1


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