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Circulating surfactant protein-B levels increase acutely in response to exercise-induced left ventricular dysfunction

De Pasquale, Carmine G; Arnolda, Leonard; DOYLE, Ian R; Aylward, Phillip; Russell, Andrew; BERSTEN, Andrew


As a result of its enormous surface area and necessary thinness for gas exchange, the alveolocapillary barrier is vulnerable to mechanical disruption from raised pulmonary microvascular pressure (Pmv). Because surfactant protein-B (SP-B) leaks into the blood stream from the alveoli in response to alveolocapillary barrier damage and exercise leads to increased Pmv, we sought to determine whether exercise results in increased plasma SP-B. Moreover, in the setting of exercise-induced left...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.0305-1870.2005.04241.x


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