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Activation mechanisms of inflammasomes by bacterial toxins

Jing, Weidong; Lo Pilato, Jordan; Kay, Callum; Man, Si Ming


Inflammasomes are cytosolic innate immune complexes, which assemble in mammalian cells in response to microbial components and endogenous danger signals. A major family of inflammasome activators is bacterial toxins. Inflammasome sensor proteins, such as the nucleotide-binding oligomerisation domain-like receptor (NLR) family members NLRP1b and NLRP3, and the tripartite motif family member Pyrin+ efflux triggered by pore-forming toxins or by other toxin-induced homeostasis-altering events such...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Cellular Microbiology
DOI: 10.1111/cmi.13309


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