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Intensity isotherms and distributions on oligonucleotide microarrays

Burden, Conrad


We describe a physico-chemical model relating measured fluorescence intensities on oligonucleotide microarrays to the underlying specific target concentration in the hybridised solution via a hyperbolic isotherm response function. The model includes various chemical reactions occurring at the microarray surface and in bulk solution during hybridisation, including specific and non-specific hybridisation, and also the effects of probe-target dissociation during the post hybridisation washing...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Conference paper
Source: 2009 IEEE Congress on Evolutionary Computation Proceedings
DOI: 10.1109/CEC.2009.4983335


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