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Regulatory T cells suppress CD8 + T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities

Haeryfar, S M Mansour; DiPaolo, R J; Tscharke, David; Bennink, Jack R; Yewdell, Jonathan W


Little is known regarding the participation of CD4+CD25 + regulatory T cells (Treg) in TCD8+ responses. In this study, we show that Treg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances TCD8+ responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced by either direct priming or cross-priming. PC61 did not enhance T CD8+ responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of TCD4+, and not on other cells...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Immunology


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